408 Efficacy of cosmeceuticals on skin structure-function utilizing preclinical models

Objective: To investigate the efficacy of three cosmeceutical products; vitamin C serum (VCS) containing Tetrahexyldecyl (THD) Ascorbate, a multi-ingredient anti-aging facial and eye moisturizer (MFM MEM), in improving epidermal dermal structure function utilizing preclinical models. Background: Dermatologists confidently recommend cosmeceuticals that demonstrate tolerability across broad patient population. Robust clinical studies are needed to substantiate efficacy, as ingredient lists provide limited insight. Companies focused on physician selected tasked with finding innovative credible methods product efficacy. Execution models can valuable results be helpful physicians, especially when supported vivo data. Methods: MatTek tissues (EpiDermFT™) were treated MFM MEM. Controls daily rinsed paralleling conditions. On Day 7, fixed, thin histological sections performed stained hematoxylin eosin (H&E) or processed antibodies for immunohistochemical analysis. Facial skin explant from 60-year-old Asian female Fitzpatrick Skin Type III incubated VCS five days, fixed H&E Masson’s Trichrome Stain (MCS). Results: MEM significantly increased epidermis thickness upregulated collagen IV elastin by 2-fold EpiDermFT™. The morphology explants demonstrated stronger network extracellular matrix proteins compared control. generated denser papillary dermis. produced dense protein fibers 145% (*p < 0.05) versus control visualized MCS. Conclusion: strongly suggest VCS, MFM, effective may offer physicians solution patients looking highly cosmeceuticals.